For all its flaws and the awful “ doctors are killing lots of patients ” reporting that it provoked, reporting that frustrated many of the investigators who carried out the IOM study because it distracted from the true message of the report, which was to encourage further investigation and a “culture of safety” in hospitals to improve the safety of patient care, the IOM report does deserve a lot of the credit for sparking the movement to improve quality and decrease medical errors over the last 17 years. At the time, I tended to agree with IOM panel member Lucian Leape, MD, who pointed out that, even if the IOM report did greatly overestimate the number of deaths due to medical errors, “Is it somehow better if the number is only 20,000 deaths? No, that’s still horrible, and we need to fix it.” Exactly.
On 26 February 1828 Palmerston delivered a speech in favour of Catholic Emancipation. He felt that it was unseemly to relieve the "imaginary grievances" of the Dissenters from the established church while at the same time "real afflictions pressed upon the Catholics" of Great Britain.  Palmerston also supported the campaign to pass the Reform Bill to extend the franchise to more men in Britain.  One of his biographers has stated that: "Like many Pittites, now labelled tories, he was a good whig at heart".  The Roman Catholic Relief Act 1829 finally passed Parliament in 1829 when Palmerston was in the opposition.  The Great Reform Act passed Parliament in 1832.
It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.