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Humans and other mammals have an XY sex-determination system : the Y chromosome carries factors responsible for triggering male development. The "default sex," in the absence of a Y chromosome, is female-like. Thus, XX mammals are female and XY are male. In humans, biological sex is determined by five factors present at birth: the presence or absence of a Y chromosome (which alone determines the individual's genetic sex ), the type of gonads , the sex hormones , the internal reproductive anatomy (such as the uterus in females), and the external genitalia.