Everyone should take such nutritional supplements daily for a lifetime because of all the health benefits provided by nitric oxide. Since NO declines appreciably with age, I suggest that men and women begin taking such nutritional supplements at a relatively young age, such as between 20 and 35 years of age. The younger the better. Having indicated that, it’s never too late to begin at any age because you will still enjoy the health benefits of nitric oxide at any age. I recommend strongly that women take products to boost their nitric oxide, and they should begin many years prior to onset of menopause. The reason for this pertains to the levels of estrogen in women, which decline sharply during and after menopause. Estrogen is well known to stimulate the production of NO, and prior to the onset of menopause women produce more NO than do men of equivalent age. Consequently, prior to menopause, women are more protected than are men of equivalent age against cardiovascular disease associated with low levels of NO, such as stroke and heart attack. However, big changes occur in women after menopause. The sharp decline in estrogen causes a simultaneous decline in NO production and thereby increases the risk for stroke and heart attack in women compared with men of equivalent age. Therefore, I recommend that women begin boosting their nitric oxide levels between 20 and 35 years of age and continue to do so daily for a lifetime.