The dose of haloperidol decanoate injection 50 mg/mL or haloperidol decanoate injection 100 mg/mL should be expressed in terms of its haloperidol content. The starting dose of haloperidol decanoate should be based on the patient's age, clinical history, physical condition, and response to previous antipsychotic therapy. The preferred approach to determining the minimum effective dose is to begin with lower initial doses and to adjust the dose upward as needed. For patients previously maintained on low doses of antipsychotics (. up to the equivalent of 10 mg/day oral haloperidol), it is recommended that the initial dose of haloperidol decanoate be 10–15 times the previous daily dose in oral haloperidol equivalents; limited clinical experience suggests that lower initial doses may be adequate.
Cigarettes laced with the acetate were offered to Augie without his knowledge of the content. Augie, who had served time in prison for assault and murder, had been one of the world's most notorious drug dealers and smugglers. He operated an opium alkaloid factory in Turkey and he was a leader in the Italian underworld on the Lower East Side of New York. Under the influence of the drug, Augie revealed volumes of information about the under world operations, including the names of high ranking officials who took bribes from the mob. These experiments led to the encouragement of Donovan. A new memo was issued:
Not all of the following adverse reactions have been observed with every phenothiazine derivative, but they have been reported with 1 or more and should be borne in mind when drugs of this class are administered: extrapyramidal symptoms ( opisthotonos , oculogyric crisis, hyperreflexia, dystonia, akathisia , dyskinesia, parkinsonism) some of which have lasted months and even years- particularly in elderly patients with previous brain damage; grand mal and petit mal convulsions, particularly in patients with EEG abnormalities or history of such disorders; altered cerebrospinal fluid proteins; cerebral edema ; intensification and prolongation of the action of central nervous system depressants (opiates, analgesics, antihistamines , barbiturates, alcohol), atropine , heat, organophosphorus insecticides; autonomic reactions (dryness of the mouth, nasal congestion , headache, nausea, constipation, obstipation, adynamic ileus , ejaculatory disorders/ impotence , priapism , atonic colon , urinary retention, miosis and mydriasis ); reactivation of psychotic processes, catatonic -like states; hypotension (sometimes fatal); cardiac arrest; blood dyscrasias ( pancytopenia , thrombocytopenic purpura , leukopenia, agranulocytosis, eosinophilia , hemolytic anemia , aplastic anemia ); liver damage (jaundice, biliary stasis ); endocrine disturbances ( hyperglycemia , hypoglycemia , glycosuria, lactation, galactorrhea , gynecomastia , menstrual irregularities, false-positive pregnancy tests); skin disorders ( photosensitivity , itching, erythema , urticaria , eczema up to exfoliative dermatitis ); other allergic reactions ( asthma , laryngeal edema, angioneurotic edema, anaphylactoid reactions); peripheral edema; reversed epinephrine effect; hyperpyrexia; mild fever after large . doses; increased appetite; increased weight; a systemic lupus erythematosus-like syndrome; pigmentary retinopathy ; with prolonged administration of substantial doses, skin pigmentation , epithelial keratopathy, and lenticular and corneal deposits.